THE PRE-MENSTRUAL SYNDROME

Katrina had married at the age of 19 against the advice of parents and friends. By the age of 22 she had two beautiful toddlers and a successful husband who doted on his children. Katrina should have been blissfully happy, but she wasn't. For two weeks before her periods, she became morose, irritable and hurtful to her family. She lost interest in sex and felt ugly and unloved. When her menstrual flow began, the dark clouds dissolved and she became her carefree self again but with bitter memories of how she had hurt those she loved. She became the caring mother and wife and resumed her painting and pottery as an expression of her creative spirit. Life was good again up until ovulation began and then, with monotonous regularity, the dark storm clouds gathered around.
Bettina, aged 37 had a vastly different lifestyle to Katrina. She was the typical 20th-century career woman, an executive in a multi-national corporation. She told her friends that she had simply forgotten to have children and marriage was not on her agenda in the context of her sixty-five-hour working week. There were many who envied her, but underneath her cool executive veneer, Bettina was starting to crack. She jumped down the throats of her colleagues, mixed up appointments and became confused for about seven days before each period. She made obvious and serious mistakes and blamed others for not covering up for her inadequacies. The only way Bettina could cope during the week before her period, was by drinking more alcohol and chain-smoking. She was wracked by vascular-tension headaches for three days before her periods and needed frequent doses of painkillers to keep going. As soon as her period began, her headaches vanished and she became once again the cool, calm, collected executive with the seemingly perfect veneer. Deep down Bettina knew that if this monthly imbalance continued she would be burnt out by the age of 45.
Perhaps you can see yourself in these two very different women. As a doctor I see hundreds of such cases in my surgery every year. It is the classic, woeful tale of pre-menstrual syndrome or PMS. Most women will have heard of PMS as it has received extensive coverage in the press and media, but it still remains a misunderstand and poorly treated issue.
PMS is surprisingly common and surprisingly variable. About 50% of women in their reproductive years will notice unpleasant mental and physical changes in themselves sometime in the two weeks before the menstrual bleeding begins.
PMS is the medical term used to describe the collection of different mental and physical problems that may occur during the second half of the menstrual cycle. There are many different problems and symptoms and the important clue is not their nature but the cyclical timing of the symptoms
If the symptoms are due to PMS, they will begin in the second half of the monthly menstrual cycle, sometime after ovulation and will disappear once the menstrual flow begins. The symptoms will then reappear after ovulation occurs in the next menstrual cycle and so the cyclical repetitive nature of PMS will become apparent. Some women will notice symptoms for the full two weeks preceding bleeding while others will feel unwell for only several days before bleeding. Some months may be worse than others with a variation in the intensity and type of symptoms. There are many possible symptoms of PMS and indeed Dr. Katharina Dalton, a world authority on this subject has identified 150 of them. Once again, it is not the type of symptoms but the cyclical relationship of the symptoms before menstrual bleeding that distinguishes PMS from other medical disorders.

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EPILEPSY AND PREGNANCY

Women with epilepsy are quite often concerned about getting pregnant. There appear to be five reasons for this concern. They wish to know:
if they are likely to hand their epilepsy on to their children;
whether their fits will get worse during pregnancy;
whether it is safe for the baby that the mother should take anticonvulsants drugs during pregnancy;
if there will be any problems in the newborn baby from these drugs;
if they can safely breast feed the baby.
With regard to handing on epilepsy to one’s children – as mentioned earlier, if one parent has epilepsy, the chances of one of the children having epilepsy are no greater than in the population at large. If both parents have epilepsy, it would appear that the risk of a child having epilepsy is about 10 per cent. So in fact the chance of a child inheriting epilepsy, particularly idiopathic epilepsy, is negligible.
As far as seizures during pregnancy are concerned, the situation is not as clear as it might be. There is evidence that for some women, seizure control may deteriorate, while for others there may in fact be no change or even an improvement. A patient told me recently that “she would like to remain pregnant forever” as she had not had a single fit during her pregnancy, compared with six fits in the preceding nine months!
As a general working rule, it is suggested that people who have more than one grand mal fit a month are those who are most likely to have a deterioration in seizure control during pregnancy. The deterioration, if it occurs, is most likely during the first three months of pregnancy. There are a number of theories why this may happen, but none has been proved. It may be of value to check the blood anticonvulsant levels during pregnancy, especially if there is a deterioration in seizure control. The blood levels may fall, necessitating an increase in dosage during the pregnancy.
The main concern for parents is whether the anticonvulsants can harm the unborn baby (foetus). It is known by most people with epilepsy that this is a potential hazard. The effects include physical abnormalities in the baby, a process known as teratogenesis. Abnormalities have been reported in the offspring of mothers on all the commonly used anticonvulsants with the exception of carbamazepine. This is particularly applicable to phenytoin, barbiturates and sodium valproate. Babies born to mothers who have been on carbamazepine have not been shown to have any physical abnormalities, but have a smaller head size than other babies. This has not been shown to be any handicap to the babies who have been followed up for five years.
The risk of abnormalities in the baby is difficult to assess, but it seems to be most common in mothers on polytherapy (receiving numerous drugs), especially if they are on three or more anticonvulsants. The risk in mothers on phenytoin, with or without other medications, appears to be about a 10% chance of the baby showing features of the ‘foetal hydantoin’ syndrome. This syndrome consists of cleft palate, abnormalities of the fingers, possible heart abnormalities and mild mental retardation. Thus, at present, if it is possible, it would seem wise to try to change patients over to carbamazepine before conception. This may not be possible in all patients and, of course, many women will first visit their doctor when already pregnant, at which time there is no purpose in making the change.
Anticonvulsants taken by the mother during pregnancy may have some effects on the baby immediately after birth, as they are transmitted to the baby across the placenta. These include the possibility of a mild bleeding tendency and some drowsiness. In mothers who have been taking barbiturates, the infant may occasionally show features of a withdrawal reaction with irritability, jitteriness and poor sucking. None of these features is [...]

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